At the 10th ACM International Conference on Nanoscale Computing and Communication Coventry, UK, September 20-22, 2023, Mohammad Zoofaghari, Martin Damrath, Mladen Veletic, Krizia Sagini, Jacob Begsland, Alicia Llorente Martinez and Ilangko Balasingham received "Best Paper Award" - "In-silico Model for Tumor Diagnosis based on Bloodstream Penetrating Extracellular Vesicles". Extracellular vesicles (EVs) are tiny particles released in a natural way from cells in the human body. These minuscule structures show promise as natural carriers for drugs and disease markers, especially in cancer. In this paper, we provide a novel computer model that simulates how EVs released by cancer cells travel through tissues, enter the bloodstream, and circulate in blood vessels. This model introduces an exciting diagnostic approach for detecting tiny tumors by measuring how well EVs penetrate the circulatory system. The simulations indicate that this approach is sensitive to tumor size, offering a potential non-invasive method for early disease diagnosis, particularly for cancer.