Programs

30.11.2012

Research groups

ANESTHESIA RESEARCH|TECHNOLOGY RESEARCH|RADIOLOGY RESEARCH|MEDICAL PHYSICS RESEARCH|CLINICAL RESEARCH


ANESTHESIA RESEARCH | Section manager: Per Steinar Halvorsen, MD, PhD

Medical sensors
Leader: Professor Erik Fosse MD, PhD

Research subject:
Advanced cardiovascular monitoring

Technological advances and a better understanding of human physiology have allowed the development of medical sensors, which can be used for optimize diagnosing and treatment of disease states.

The Intervention Centre is coordinating a joint project called “Micro-Heart” for detection of heart motion changes. The goal is to develop a system for early detection of perioperative regional ischemia and monitoring of global cardiac function by miniaturized motion sensors, such as epicardial 3-axis accelerometers and ultrasound sensors. The techniques have been used successfully in both experimental animal and clinical studies. The “Micro-Heart” project is in close collaboration with Vestfold University College in Tønsberg. The Intervention Centre is responsible for the clinical research activity, whereas Vestfold University College is responsible for miniaturizing of the sensors and for incorporating the sensors into temporary pace-maker leads. The idea of using 3-axis accelerometer in perioperative ischemia detection is patented: Patent number: NO 20016385.

The accelerometer and miniature ultrasound sensors are also used in experimental models for assessing cardiomyopahty in sepsis and therapeutic hypothermia.

Together with the Department of Clinical Engineering, Professor Sverre Grimnes, this group was also invol-ved in the development of a sensor for measuring the sweat production in different parts of the body by a bio impedance technique. This sensor provides continuous clinical information on the intensity of sympathetic nervous activity.

Projects                                                    Project leader          Financing

Miniaturized epicardial ultrasound probes     Professor                 HSØ
for perioperative myocardial monitoring       Thor Edvardsen    

Myocardial function in graded ischemia        Mentor, Professor      NFR
assessed by myocardial sensors                 Erik Fosse    

Cardiomyopathy                                       Professor
in sepsis                                                 Thor Edvardsen

Ultrasonic diagnostics in acute                    Professor                  HSØ
and chronic heart failure                            Thor Edvardsen

Circulatory and cardiac effects                    Professor                   HSØ
of transaortic valve implantation (TAVI)       Erik Fosse

Accuracy of accelerometer                           Professor                  HSØ
measurements in cardiac monitoring           Erik Fosse

Wireless sensor communication                   Professor                  IVS
in advanced medical settings                      Erik Fosse

Development of a sensor                            Professor                  NFR
for sweat measurement                              Sverre Grimnes

Cardiomyopathy                                         Professor                 Dep. of Cardiology
in therapeutic hypothermia                          Jan Fredrik Bugge     OUS

PhD candidates:
Andreas Espinoza, MD, Stefan Hyler, MD,
Siv Hestenes, MD, Ole-Johannes Grymyr, MD,
Jo Eidet, MD, Harald Bergan, MD,
Christan Trondstad, MSc, Karl Øyri, Cand San

Post Doc:
Espen Remme, MSc, PhD


Biosensor Research Group
Leader: Professor Tor Inge Tønnessen MD, PhD

The Biosensor research have three main branches; ?1) the biologic basis for ischemia and the choice of parameters for detection thereof, 2) the development of a specific pCO2 sensor and 3) developing methods for early detection of rejection in transplant patients. The biologic basis has been studied through animal experiments.

The Biosensor research have three main branches:

1)    The biologic basis for ischemia and the choice of parameters for detection thereof

2)    The development of a specific pCO2 sensor

3)    Developing methods for early detection
of rejection in transplant patients

Ongoing PhD programs in 2011:

1.    Lars Wælgaard, MD:
New clinical methods for detection of ischemia        
Mentor: Tor Inge Tønnessen, the Intervention Centre/Dept of Anaesthesiology, Oslo University Hospital

2.    Søren Pischke, MD:
Biosensors for detecting cardiac ischemia
Mentor: Tor Inge Tønnessen, the Intervention Centre/Dept of Anaesthesiology, Oslo University Hospital
and Tom Eirik Mollnes, IMMI, Oslo University Hospital

3.    Håkon Haugaa, MD:
Microdilaysis monitoring in transplanted patients        
Mentor: Tor Inge Tønnessen, the Intervention Centre/Dept of Anaesthesiology, Oslo University Hospital
and Tom Eirik Mollnes, IMMI, Oslo University Hospital



Complement Research Group
Leader: Professor Tom Eirik Mollnes, MD, PhD

Research subject:
The role of complement in human disease

Complement is part of the innate immune system protecting the host against invading micro-organisms. Regulatory control mechanisms normally prevent the system from extensive and systemic activation, thereby protecting the host from self damage. Under various disease conditions complement is improperly activated, either locally leading to tissue damage or systemically with risk of serious homeostatic disturbances.

A primary research goal for the Complement Research Group is to elucidate the role of complement as a primary inducer of the inflammatory reaction and thereby form a basis for a future therapeutic approach in complement-mediated disease processes.

For this purpose we have developed novel assays for detection and quantification of complement activation products based on monoclonal antibodies to activation dependent epitopes on a number of complement components; the most important one being the assay for TCC (the terminal SC5b-9 complement complex). These assays are used to detect complement activation experimentally and clinically and to evaluate the effect of various complement inhibitors in experimental models. In a novel in vitro human whole blood model where all potential inflammatory mediators are able to interact mutually, we are currently studying the effect of complement inhibition on a number of arms of the inflammatory network. In particular we are focusing on the cross-talk between complement and the Toll-like receptors with emphasize on CD14. The main current clinical and experimental animal projects aims to elucidate the role of complement and CD14 in sepsis, systemic inflammatory response, ischemia-reperfusin injury and transplant rejection.

Web site: www.med.uio.no/klinmed/forskning/grupper/komplementgruppen/


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TECHNOLOGY RESEARCH | Section manager: Ole Jakob Elle, PhD   

Wireless sensor networks
Group leader: Professor Ilangko Balasingham, PhD

The sensors, signals, and systems research group aims to facilitate deployment intelligent sensors and systems for different procedures in surgery, minimal invasive therapy and ambient point of care monitoring. The main focus area of research is in efficient design and development of novel sensors, power efficient real time signal processing algorithms, sensor data fusion, and wireless communication solutions for in vivo and ex vivo purposes. Some of our activities have been on studying the use of ultra wide band medical radars to estimate blood pressure, blood flow and tissue/organ motions. Furthermore, novel signal processing algorithms to facilitate power efficient processing of digital data in sensors, which are popularly called as sensor nodes in wireless communications networks. The digital sensor data fusion and multi parameter analysis are also active areas of research. We are working to design reliable, power efficient and robust wireless body area sensor networks for in vivo (implantable) and ex vivo use.

We have a close collaboration with the Department of Electronics and Telecommunications at the Norwegian University of Science and Technology (NTNU) in Trondheim and several national and international research institutions and companies participate in different projects.

In addition to several ongoing projects, the group participates in the projects “Oslo Medtech Cluster” and COST action “Cognitive Radio and Networking for Cooperative Coexistence of Heterogeneous Wireless”. Project “Oslo Medtech Cluster” is funded by Innovation Norway, SIVA and Research Council of Norway through the ARENA program. The COST project IC 0902 “Cognitive Radio and Networking for Cooperative ?Coexistence of Heterogeneous Wireless” is funded by the COST, Research Council of Norway and Ministry of Foreign Affairs for 4 years.    

The research group, which is split between Oslo and Trondheim, has presently 7 PhD fellows and 6 Post doctoral fellows employed through the projects. Dr. Sang-Seon Byun joined the group as an ERCIM Postdoc fellow in 2007, where he will continue working in the WISENET project for another year and will be located at NTNU in Trondheim. Dr. Ali Khaleghi, who joined us as a PostDoc fellow in the WISENET project returned back to Iran in December 2009 but came back as a visiting Professor in June 2010 for 3 months. Dr. Qinghua Wang joined the group as an ERCIM Postdoc fellow in 2010 and will be located at NTNU in Trondheim for one year. Dr. Jianguo Ding and Dr. Alex Cartagena Gordillo, worked as ERCIM Postdoc fellows, returned to their home countries China and Peru, respectively.

PhD programs:

1.    MSc. Stig Støa:
Ultra wide band impulse radio
Mentors: Ilangko Balasingham and Erik Fosse,
the Intervention Centre, Oslo University Hospital and        
Dag Wisland and Tor Sverre Lande, University of Oslo 

2.    MSc Hessam Moussavinik:
Super robust short range wireless sensor network        
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital. Geir Øien and Tor Ramstad,
Norwegian University of Science and Technology,
and Niels Aakvaag, Multihop Com AS

3.    MSc Minh-Long Pham:
Distributed signal processing for power efficiency        
Mentor: Tor Ramstad, Norwegian University of Science and Technology
and Ilangko Balasingham, the Intervention Centre, Oslo University Hospital

4.    MSc Fatemeh Kazemeyni:
Modelling tools and optimization of wireless sensor network
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital. Olaf Owe and Einar Broch Johansen,
University of Oslo

5.    MSc Lars Erik Solberg:  
UWB medical radar for estimating blood pressure        
Mentor: Ilangko Balasingham and Erik Fosse,
the Intervention Centre, Oslo University Hospital
and Svein-Erik Hamran, Norwegian Defence
Research Establishment

6.    Nguyen Trung Hieu:
Information theoretical bounds for wireless sensor networks
Mentor: Tor Ramstad. Norwegian University of Science and Technology
and Ilangko Balasingham, the Intervention Centre, Oslo University Hospital

7.    Babak Moussakhani:
Signal processing for robust invivo-exvivo communication
Mentor: Ilangko Balasingham, the Intervention Centre, Oslo University Hospital
and Tor Ramstad, Norwegian University of Science and Technology


Postdoctoral fellows:

1.    Dr. Sang-Seon Byun:
Development of Cognitive wireless sensor networks        
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Norwegian University
of Science and Technology

2.    Dr. Pål Anders Floor:
Signal processing for robust wireless communications 
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Tor Ramstad,        
Norwegian University of Science and Technology

3.    Dr. Raul Chavez-Santiago:
Cognitive UWB sensor networks
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Norwegian University
of Science and Technology

4.    Dr. Jianguo Ding:
Deployment and management of wireless sensor networks
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Norwegian University
of Science and Technology

5.    Dr. Alex Cartagena Gordillo:
On antennas and modulation for UWB sensor networks
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Norwegian University
of Science and Technology

6.    Qinghua Wang:
Sensor network localization
Mentor: Ilangko Balasingham, the Intervention Centre,
Oslo University Hospital and Norwegian University
of Science and Technology


Visiting professor:

Assistant Professor Ali Khaleghi:
Invivo and exvivo UWB applications
The K. N. Toosi University of Technology,
Tehran, Iran.


Medical robotics application and control

Group leader: Ole Jakob Elle, PhD

Surgical robotics has been a research topic of The Intervention Centre since 1998. The Zeus Micro Joint telemanipulator has been used for animal studies performing coronary bypass-surgery and human trials for thoracoscopic IMA-takedown and sympatectomy. Through this work, spin-off research projects such as head-tracking as a control modality for a robotic scope-holder and haptic feedback to give the operator the feeling of touch when remotely controlling the robot has been initiated. Industrial and academic contact with Patric Finlay (Prosurgics Lmt., Medimation Lmt.) has been fruitful within the area of neurorobotic systems, and a cross-disciplinary research collaboration between engineers and neurosurgeons were established through this contact. The project was aimed at precise positioning of a tool within target points in the brain using image guidance and without the use of a stereotactic frame, by use of the neurosurgical PathFinder robot. This project is on hold due to software upgrade of the PathFinder robot as a result of our preliminary use of the system.

In 2005 the PhD fellow Edvard Nærum was hired with the research topic of haptic and tactile feedback in remote surgery. Edvard Nærum was in 2008 at a research stay at Seattle University, USA hosted by Professor Blake Hannaford. Two papers were published in 2009 based on work performed with Balke Hannaford, and two more publications based on the collaboration with Hannaford are in preparation. Hannaford is an important academic contact within the robotic research field. Edvard Nærum is now working with his last study, and is planning to complete his PhD within 2011.

Katholieke Universitat Leuven was partner in the Marie Curie project ARIS*ER, which was coordinated by The Interventiona Centre. As a spin-off from ARIS*ER, the EU-Strep proposal SCath (Smart Catheterization) was granted in 2009 initiated by Katholieke Universitat Leuven. The Intervention Centre is partner in this project, where the aim is to develop a navigation plat-form and a robotic control system for safer and more precise positioning of catheter introduced devices. The SCath project runs 2011 – 2014.

Ole Jakob Elle holds a position at The Department of Informatics, University of Oslo as an Adjunct Associate Professor. In 2009 a four year PhD-scolarship was decided to be dedicated to research work within robotic surgery at The Intervention Centre. The Candidate started his work in autumn 2010.

Department of Ear Nose and Throat is doing Cochlea Implants in the Angio Lab at The Intervention Centre. Ralf Greisiger is taking his PhD at Department of Informatics in the development of an expert system for optimising the placement of Cochlea Implants.

In 2010 EU granted a new project on automation in surgery. The project name is I-Sur (Intelligent Surgical Robotics) and aims at develop intra-operative sensing, intelligent control and reasoning systems in order to explore the degree of automation possible. The project that is coordinated by Professor Paolo Fiorini at University of Verona starts in Mars 2011 and runs until October 2014. The Intervention Centre responsibility is within intra-operative sensing and the development of advanced control algorithms. The project will fund one PhD and one Postdoc that was employed in 2011.


PhD programs:

The Robotic research group had four PhD projects running in 2011:

1.    M.Sc. Edvard Nærum:
Haptic and tactile feedback in remote surgery        
Mentor: Ole Jakob Elle and Erik Fosse,
The Intervention Centre, Oslo University Hospital

2.    M.Sc. Tangui Morvan:
Collision detection and visualisation system
to help and guide the surgeon while doing
tele-manipulated surgery
Mentor: Eigil Samset and Ole Jakob Elle,
The Intervention Centre, Oslo University Hospital

3.    M.Sc. Kim Mathiassen:
Semi-autonomous robotic systems for use in        
medical diagnostics and treatment
Mentors: Ole Jakob Elle at The Intervention Centre,
Oslo University Hospital and Kyrre Harald Glette
and Mats Erling Høvin at Department of Informatics,
University of Oslo

4.    M.Sc. Dilla Handini (I-SUR):
US imaging as an intra-operative sensing
for Intelligent Surgical Robotic System
Mentos: Ole Jakob Elle at The Intervention Centre,
Oslo University Hospital


Postdoctoral fellow:

1.    Nguyen Ho Quoc Phuong (I-SUR):
Reasoning and situation awareness engine
for automatic robotic control using real-time        
sensing including visual servoing


Image Processing Visualization and Navigation
Group leader: Ole Jakob Elle, PhD

Most minimally invasive procedures restrict the access and direct vision to the regions which require surgery. Such procedures require intra-operative image modalities such as ultrasound or endoscopic images to be able to monitor the surgery. In many cases this information is not sufficient to perform the procedure accurately and safely. Merging information acquired pre-operatively, mainly from for instance MRI, CT or PET, with intra-operative data can increase the basis for decisions and thereby improve the safety and accuracy of the procedure. The image processing, visualization and navigation group develops cutting edge technological solutions which support minimally invasive procedures. As the title of the group indicates, the research focus is divided into three areas. Image processing methods are key elements in any software system which supports minimally invasive procedures. In particular, we are focused on developing real-time image-segmentation and -registration methods where segmentation methods finds important anatomical structures such as tumors and vessel structures in images, while registration methods enables fusion of images. Visualization and navigation is required to present the medical images to the surgeon intra-operatively. We are developing visualization systems which use advanced techniques such as augmented reality and volume rendering for this purpose.

The project “Mathematical and computational methods for co-registering multimodal medical images” (MATMED) is funded under the eScience program at the Norwegian Research Council for the period 2007–2011. It is a joint project between the Intervention Centre, Centre for Mathematics and Applications (CMA) at UiO and Center for Integrated Petrolium Research at the University of Bergen and funds three PhD positions. Petter Risholm defended his PhD within the MATMED-program 31st of May 2011 with the title “Intra-operative deformable registration”.

In 2009 the Marie Curie project IIIOS (Integrated Intra-operative Imaging Operating System) was funded by EU. The Intervention Centre is a partner in this project. IIIOS is a Marie-Curie Research Training Network for the education of young researchers, and in connection with that each partner has the responsibility of arranging different training cources for the young researchers within the project throughout the duration the project. Part one of the IIIOS-Training course for 2010 were arranged by the The Intervention Centre, Oslo University Hospital on the 26th to 27th of August 2010, and had the title “Interventional MRI in image guided procedures”. The project is financing two PhD fellows at The Intervention Centre. The project runs until October 2013.

In February 2010 the EU funded project SCath (Smart Catheterization) started. The project is coordinated by Katholieke Universitat Leuven. The Intervention Centre is partner in this project, where the aim is to develop a navigation platform and a robotic control system for safer and more precise positioning of catheter introduced devices. The SCath project runs 2011 – 2014. The main role of The Intervention Centre is to develop improve the accuracy of the tracking information used in the navigation of  the catheter and the development of better registration algorithms for effective motion compensation and correction of deformation in model based navigation.


PhD programs:

The group had four ongoing PhD programs in 2011:

1.    Tangui Morvan (ARIS*ER- Early stage researcher):         
Development of general purpose algorithms for collision
detection using GPU (Graphics Processing Unit).
Mentor: Eigil Samset and Martin Reimers,
Department of Informatics, University of Oslo

2.    Sergiy Milko (ARIS*ER Early stage researchers):         
Automatic registration of Ultrasound
and CT/MRI images.
Mentors: Prof. Eigil Samset and Timor Kadir,            
Siemens Magnet Technologies

3.    Petter Risholm (MATMED PhD student):
Intra-operative deformable registration.
Mentor: Prof. Eigil Samset, The Intervention
Centre, Oslo University Hospital

4.    Eivind Lyche Melvær (MATMED PhD student):         
Reconstruction of 3D images from free-hand
2D ultrasound.
Mentors: Prof. Knut Mørken, CMA/UiO
and Prof. Eigil Samset, The Intervention Centre,        
Oslo University Hospital

5.    Egil Bae (MATMED PhD student):
Image Segmentation and Reconstruction
using level sets and graph cuts.
Mentors: Prof. XueCheng Tai, CIPR/UiB
and Prof. Eigil Samset, The Intervention Centre,        
Oslo University Hospital

6.    Abubakr EL-Dirdiri (IIIOS):
Development of methods for the Integration
of catheter tip tracking into the 3T MR.
Mentor: Frederic Courivaud and Ole Jakob Elle
at The Intervention Centre

7.    Rahul Kumar (IIIOS):
Develop new effective segmentation algorithms        
for the facilitation of endoscopic and cardio            
vascular navigation.
Mentor: Ole Jakob Elle and Bjørn Edwin at
The Intervention Centre. Fritz Albrigtsen and            
Martin Reimers at Department of Informatics        
University of Oslo. Thomas Langø at Sintef Health

8.    Ralf Greisiger:
Objective Measurements and Cochlear Implants Imaging
Mentor: Greg Eigner Jablonski at Department of        
Ear Nose and Throat at Oslo University Hospital,         
Ole Jakob Elle and Per Kristian Hol at The
Intervention Centre and Jon K. Shallop Associate        
Professor of Audiology and Senior Consultant at        
Mayo Clinic Medical School, Rochester, Minnesota.

Postdoctoral fellow:
Hugues Fontenelle PhD (SCath):
Algorithms for the compensation of inaccuracies
in magnetic tracking when used in an OR setting.

Software Developer:
Rafael Palomar (SCath):
Implementation of navigation platform and the development
of methods for compensation of motion and deformation
in catheter navigation.


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IMAGING RESEARCH AND IMAGE GUIDED INTERVENTION | Section manager: Per Kristian Hol, MD, PhD

Imaging research and image guided intervention
Group leader: Per Kristian Hol, MD, PhD

A number of research projects using the 3T MR scanner or the combined angiographic suite are performed in corporation with different academic partners, including Departments of Neuropsychiatry and Psychosomatic Medicine, Oncology, Ear Nose and Throat, Neurosurgery, Neurology, Anesthesiology and Radiology. The research topics cover brain, spine, liver, prostate, brachial plexus and inner ear.

A total of 12 PhD programs used the angiographic suite or the MR scanner for their research in 2011:

1.    Cand. Med. Trygve Kjelstrup:
Axillary plexus block, nervestimulator,
ultrasound and MRI
Mentors: Øivind Klaastad and Harald Breivik,            
Department of Anaestesiology, and Per Kristian Hol,        
The Intenvention Centre, Oslo University Hospital

2.    Cand. Med. Torbjørn Elvsåshagen:
Neuroplastisity in patients with bipolar disorders        
Mentors: Ulrik Frederik Malt and Stein Andersson,        
Department of Neuropsychiatry and Psycho-
somatic Medicine, Oslo University Hospital.
Espen Dietrichs, Department of Neurology,
Oslo University Hospital. Ole Andreassen,
Institute of Psychiatry, University of Oslo

3.    M.Sc. Ralf Greisiger:
Cochlear Implants and DynaCT imaging
Mentors: Greg E. Jablonski and Terje Osnes,
Dept of Ear Nose and Throat , Oslo University        
Hospital. Ole Jacob Elle and Per Kristian Hol,
The Intervention Centre, Oslo University Hospital        
and Jon K. Shallop, Mayo Clinic Medical School 

4.    Cand. Med. Jarle Sundeth:
Faktorer som har betydning for resultatet av kirurgisk behandling av nakkeprolaps
Mentors: Frode Kolstad, Department
of Neurosurgery and Øystein Nygård,
Trondheim University Hospital

5.    Cand. Med. Kristin Evensen:
The vulnerable carotid artery plaque
Mentor: David Russell, Department
of Neurology, Oslo University Hospital

6.    Cand. Med. Karolina Ryeng Skagen:
The vulnerable carotid artery plaque
Mentor: David Russell, Department
of Neurology, Oslo University Hospital

7.    Cand. Med. Geir Ringstad:
Assessment of Intracranial Pulsatility and Cardiac-beat Intracranial Volume Change using MRI
Mentors: Per Kristian Eide, Department of Neuro-        
surgery, Kyrre E. Eblem, The Intervention Centre,        
and Noam Alterin, University of Miami, Florida, USA

8.    Astrid Almaas, Elin Blakstad, Sissel Moltou
and Kenneth Strømmen:
Nutrition, growth and development of premature children
Mentor: Christian A. Drevon, Department of
Nutrition, Institute of Basic Medical Sciences,        
University of Oslo

9.    Cand. Psych.Gudmundur Skarphedinsson:
I vivo MR spectroscopy as a neuroimaging diagnostic study in children and adolescents with obsessive-compulsive disorders
Mentor: Tord Ivarsson, Regionsenter for barn
og unges psykiske helse (PBUP Øst og Sør)


MR guided high intensity focused ultrasound treatment
Group leader: Per Kristian Hol, MD, PhD

The 3T MR scanner at the Intervention Centre has integrated High Intensity Focused Ultrasound (HIFU) equipment as part of a research agreement with Philips Medical Systems. HIFU-therapy is completely non-invasive as the ultrasound energy is delivered outside the body, but focused in defined areas in an organ. MR-given real-time temperature feedback optimizes the procedure. In 2011 projects on ablation of uterine fibroids and liver were on-going. Program to start ablation treatment of prostate are under preparation.


PhD programs:

Cand. Med. Eric Dorenberg:
Aspects of interventional procedures for treatment of uterine fibroids
Mentors: Jarl A. Jacobsen, Department of Radiology, Oslo University Hospital
and Per Kristian Hol, The Intervention Centre, Oslo University Hospital


Neuro cognitive imaging
Group leader: Associate professor Tor Endestad

The fMRI group at the Center for Study of Human Cognition at UiO work with basic resarch related to cognitive functions. 2010 has been a year with many technical challenges and recollection of data.

The group is engaged in the study of memory and cognitive control. In one of the programs studies of early visual memory are combined with attention to better understand the building block of the human memory system. In addition memory errors (false memories) and the relationship between executive functions and impulse control are studied. Both patients with focal brain injuries and psychological disturbances are included in the research. In another line of projects studies of brain damaged patient address frontal lobe damage, hormone influence on cognitive functions.

Several projects with cooperation between the Centre and RH (FRONT, Cerebellum) were started in 2008 and continued in 2010. For all these projects data collection has been or are close to be finalized.  

In addition to basic research, the group participate in the development of functional MRI as part of pre-surgical planning and improvement of neuropsychological diagnostics.

A new treatment project has been established in cooperation with RedCord. A physioterapy based method for neck pain relief will be studied as a pre and post treatment study.

A cooperation with the University of Lund on linguistic processing has been started in 2011 and will continue in 2012.

Ongoing projects that continue in 2012:

PhD Projects:

1.    Can the brain make sense of nothing, fill in of the Blind spot
PhD student: Dag Alnes
Principal res: Tor Endestad,
Svein Magnussen

2.    Plasticity in the human visual system
PhD student: Markus Handal Sneve
Principal res: Tor Endestad, Svein Magnussen

3. FRONT Frontal Lobe Injury and cognition
PhD Students: Marianne Løvås, Ingrid Funderud
Principal Res: Tor Endestad, Anne Kristin Solbakk,        
Magnus Lindgren

4.    Cerebellar damage and cognitive control
PhD Student: Torgeir Moberget
Principal Res: Tor Endestad, Stein Anderson


Post Doc projects:

1.    Decision making
Post Doc: Guido Guido Biele
PhD: Renata Suter

2.    Placebo treatment of pain
Post Doc: Siri Leknes
PhD: Dan Mikael Ellingesen

Master students:

1.    Unconscious processing of emotions
Master student: Laura Bakke
Principal Res: Tor Endestad, Bruno Laeng

2.     Hippocampus and temporal lobe activation
Master Student: Laura Bakke
Principle Res: Tor Endestad

3.    Action verbs
Master Student: Tommy Silnes
Principle Res: Tor Endestad


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MEDICAL PHYSICS RESEARCH | Section manager: Anne Catrine Trægde Martinsen, PhD

Advanced MR neuro imaging
Group leader: Professor Atle Bjørnerud, PhD, UiO

The main research focus of the Advanced Neuroimaging Group (ANG) is related to functional MRI applied to different neuropathological conditions. There is currently a particular focus on MR based imaging for diagnosis, prognosis- and treatment response assessment in patients with primary brain tumors (gliomas). A multi-centre study for evaluation of diagnostic efficacy of MR based perfusion imaging for diagnosis of gliomas is incorporated in the Norwegian Research Council (NRC) -financed project: Evaluation of functional Magnetic Resonance in the Diagnosis of Brain Tumors for Assessment of Clinical Efficacy (EMBRACE). As part of the EMBRACE project a new prospective study is ongoing, which will assess the clinical utility of advanced MR based imaging methods for evaluation of treatment response in high grade gliomas patients.

The ANG is a multi-disciplinary effort and is collaborating closely with many other groups both internally within the OUS and externally with world-class research groups in Europe and the US. The group also has a close link to industry through collaboration/co-development with software companies (NordicNeuroLab, Bergen, Norway and CorTechs Labs, SanDiego, USA). The group has filed several patent ?applications related to novel image processing techniques which have been sub-licensed to our industrial partners. The ANG group members are further involved in a large number of imaging studies ongoing in the Oslo-region. In particular, the group provides MR expertise in several morphometric MR studies where high resolution MRI is used to assess neuro-structural changes related to neurodegenerative ?disease, Alzheimer’s disease and normal aging.

PhD students:

Paulina Due-Tønnessen
Mentors:  Atle Bjørnerud, Kyrre Eeg-Emblem
Evaluation of functional magnetic resonance in the diagnosis of brain tumors for assessment of clinical efficacy                     

Tuva Hope  
Mentors: Atle Bjørnerud, Inge Rasmussen, Asta Håberg
MR based analysis of functional and hemodynamic parameters in brain tumors                                                               

Endre Grøvik  
Mentors: Kjell-Inge Gjesdal, Atle Bjørnerud,
Kathinka Kurz, Tryggve Storaas
Magnetic Resonance Imaging: a novel method for improved morphologic and functional assessment of breast tumors            

Arvid Morell (Uppsala)   
Mentors: Atle Bjørnerud, Håkan Ahlström
Quantitative tracer based MRI perfusion – potentials and limitations                              

Per Selnes (Akershus University Hospital)   
Mentors: Tormod Fladby, Atle Bjørnerud
Understanding early events in Alzheimer’s disease pathogenesis

Guro Kahrs Rognsvåg                                   

Post Doc:
Inge Rasmussen and Kyrre Eeg Emblem


Ongoing projects      

EMBRACE

SAILOR

Magnetic Resonance Imaging:
A Novel Method for Improved Morphologic and Functional Assessment of Breast Tumors

nordicICE integration in PACS

Quantitative MR-perfusion

Automated white matter lesion quantification


Software development – nordicICE
The ANG has over the last years been central in the development of an extensive software package for advanced image processing in MRI, with special focus on dynamic analysis. The software package, called nordicICE, is now a commercial product sold in more than 20 countries. nordicICE is one of very few medical image analysis software packages for advanced perfusion analysis with full FDA-approval (510K).
At Rikshospitalet, nordicICE has been fully integrated into (Sectra) PACS and is now an integral part of routine diagnostic MR procedures, including BOLD fMRI, DTI and perpfusion analysis. The ANG is currently preparing the nordicICE software package for integration into the next generation Sectra PACS (IDS7) and also focusing on expanding the functionality of the package towards automated tumor segmentation and implementation of advanced statistical methods for computer aided diagnosis (CAD).


Physics and image processing in CT, PET-CT and nuclear medicine
Group leader: Associate professor Anne Catrine Trægde Martinsen, PhD

CT physics and technology
Challenges
Over the last 30 years, the CT technological developments have been tremendous. In Norway, the frequency of CT examinations increases and CT examinations accounted for 80% of the total population radiation exposure from medicine in Norway.  Therefore, further development of new techniques to improve image quality while reducing the radiation dose to patients is required. The main focus of the group is clinical implementation and further development of new image reconstruction algorithms and image post processing tools, such as CT perfusion, spectral imaging and iterative reconstruction techniques in clinical practice.
Projects
o    Spectral imaging and iterative reconstruction in CT imaging, image quality and radiation doses
o    ”OsloCoMet-study“: Ny metode for levermetastaseutredning hos pasienter med kolorektal kreft (CT perfusjon)
o    Mammografiscreening med nye opptaksteknikker
o    Evaluation of the quality and cost of CT scanners from all vendors on the Norwegian market
o    Interphantom and interscanner variations for Hounsfield units, homogenity and low contrast detectability in Catphan 500/600
o    “HyPerCept – Color and Quality in higher dimensions”, WP2.1: Optimizing visual and diagnostic image quality in radiography
o    Ultralow dose chest CT
o    Dosimetry in TAVI: Dose survey for  personnel and patients


Group members:
Bjørn Helge Østerås (PhD-student)
Kristin Jensen (PhD-student)
Hilde K. Andersen (PhD-student)
Kristine Gulliksrud PhD (Researcher)
Ellinor Bilet MSc (Researcher)
Siri Fløgstad Svensson MSc (Researcher)
Hilde Olerud PhD (Researcher)
Caroline Stokke PhD (Researcher)
Trond Mogens Aaløkken MD PhD (Researcher)
Yngvild Kvaale (Masterstudent)


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CLINICAL RESEARCH | Section manager: Bjørn Edwin, MD, PhD

Image guided general surgery and intervention
Group leader: Bjørn Edwin, MD, PhD

Several new techniques in laparoscopic surgery have been introduced in Norway through this group. Some of the methods are now routine procedures, like laparoscopic adrenalectomy and laparoscopic prosta-tectomy. The group validates new procedures and establishes effective training.

Education programs in minimal invasive surgery in both gastrointestinal- and urological surgery are orga-nized in collaboration with other hospitals in Norway, Sweden, Russia and Denmark.

The Department of Surgery is one of our main collabo-rators with research projects ongoing in:

•    Minimal invasive surgery on the liver, pancreas,         
stomach, oesophagus, kidney, adrenal gland
and colon/rectum

•    Minimal invasive techniques in children

•    Thermal liver ablation (HIFU and RF)

PhD students:
Irina Pavlik Mangos, MD, Airazat M. Kazaryan, MD
Martin Johanson, MSc, Tom Nordby, MD
Åsmund Avdem Fretland, MD, M Spasojevic, MD
Kim Vidar Ånonsen, MD, Rahul Prasanna Kumar, MSc
Brith Andersen, MSc


Ongoing projects      

Extracorporeal high intensity focused ultrasound ablation of liver malignancies
Project leader: Bjørn Edwin
Funding source: Norwegian Cancer Society (NCS)

Minimal invasive techniques in the treatment of patients with lesions in the endocrine organs of the abdomen
Project leader: Bjørn Edwin
Funding source: Other External

Percutaneous access and connection to visceral organs

Project leader: Bjørn Edwin
Funding source: NFR, Gothenburg University

CoMet (Randomization between laparoscopic and open liver resection for colorectal metastasis)
Project leader: Bjørn Edwin
Funding source: South-East Regional Health Authority


Project-participation      

Pancreas in tumors – investigation and clinical care
the role of surgery in the treatment pancreatic cancer
Participant: Bjørn Edwin, co-mentor PhD study
Project leader: Trond Buanes

DIVID (Diabetes – caused by virus?)
Participant: Bjørn Edwin
Project leader: Knut Dal Jørgensen

The anatomical/surgerical concequences of right colecotemy for cancer
Participant: Bjørn Edwin, co-mentor PhD study
Project leader: Dejan Ignjatovic

Managing cystic pancreatic lesions – a challenging task
Participant: Bjørn Edwin, co-mentor PhD study
Project leader: Truls Hauge

Blood vessel visualization and navigation
Participant: Bjørn Edwin, co-mentor PhD study
Project leader: Ole Jakob Elle

Outcomes in patients and their closest relatives treated for congenital heart disease with catheter
based or surgical techniques (MEQC)
Participant: Erik Fosse, professor, MD
Project leader: Brith Andersen

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Regional Core Facility

The Intervention Centre is Regional Technological Core Facility for introduction of new treatment methods and clinical testing of technology funded by Helse Sør-Øst Regional Health Authority:

Kjernefasilitet

The Intervention Centre Testbed:

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Information in Norwegian

English is the main language in this web portal. Some information is also available in Norwegian Norwegian text

Donations to Medical Research

The Interventional Centre receives donations to medical research. Questions related to donations can be sent to head of department professor Erik Fosse.

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Publications

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Annual Report 2012

2012

Annual Report 2011

Annual Report 2011

Annual Report 2010

Annual Report 2010

Roadmap Norwegian Research Infrastructure

Norwegian Roadmapp for Research Infrastructure

Annual Report 2009

Annual report 2009

Annual Report 2008

Annual Report 2008

Annual Report 2007

Annual Report 2007

New book about the Interventional Centre

New book about the Interventional Centre

Author: Erik Fosse
Publisher: Det Medisinske Selskap 2007
Price: 180 kr
Online order
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