Programs

20.06.2018 Research groups

[Clinical Research][Radiology Research][Anesthesiology Research][Medical Cybernetics and Image Processing Research][Information and Communication Technology Research][Method Development and Industry Collaboration Research][BigMed]


Clinical Research

Image guided general surgery and intervention

Group Leader: Bjørn Edwin, professor, MD

Group Members:

  • Mushegh Sahakyan, PhD student
  • Anne Waage PhD, Surgeon
  • Knut Jørgen Labori PhD, Surgeon
  • Kjersti Flatmark, professor
  • Stig Ronny Kristiansen, IT-researcher
  • Karl Øyri, PhD, Researcher
  • Dejan Ignatovic Ph.D, Surgeon
  • B.A. Bjørnbeth PhD, Surgeon
  • Trond Buanes, professor
  • Bård Røsok PhD, Surgeon
  • Airazat Kazaryan PhD, Researcher
  • Vegard Dagenborg, PhD student
  • Åsmund Avdem Fretland, PhD-student
  • Leonid Barkhatov, PhD-student
  • Sven Petter Haugvik, PhD-student
  • Davit Aghayan, PhD-student
  • Gudrun Maria Waaler Bjørnelv PhD student

Background

Minimally invasive surgery is evolving rapidly, and the need for systematic development and evaluation of these methods is great. Our group focuses on research on the results of new minimally invasive surgical techniques in addition to development of new procedures. Most of the research is conducted in the field of HPB-surgery (diseases in liver, bile ducts and pancreas) and adrenal surgery.

Ongoing Projects

  • The Oslo CoMet-study (Oslo randomized laparoscopic vs open liver resection for colorectal liver metastasis – study). Funding: HSØ
  • In addition to the evaluation of surgical and oncological results, several translational studies are performed, such as bio banking of tumour tissue, studies on the inflammatory response, health economy evaluation and pain/quality of life studies.
  • Multicentre studies on laparoscopic liver surgery
  • Research on pancreatic cancer: Examining the Role of Laparoscopic Distal Pancreatectomy in the Treatment of Pancreatic Cancer: From a Consensus Study to Randomized Controlled Trials. The main aim is to assess the oncologic outcomes of Laparoscopic Distal Pancreatectomy (LDP) in patients with Pancreatic Distal Adeno- Carcinoma, determine the prognostic factors and provide justified recommendations for its use. Funding: Kvote programmet UiO
  • The research group also does research on MRI-guided High Intensity Focused Ultrasound (HIFU) of lesions in liver and prostate. Funding: Kreftforeningen
  • Together with the University of Gothenburg, we do research on biomaterials in implants.
  • Research on imaging of liver tumours (CT, MRI, PET-CT) is conducted with other research groups at the IVS and OUS.
  • In a joint project, a method for automatic segmentation of liver anatomy including tumors is developed. The final goal is to create an interactive map for liver surgeons that will greatly ease both planning and the actual surgery.
  • Research on reasons to onset of type 1 diabetes, DiVid study.
  • Research on D3 resection of colon cancer
  • The Group is also involved in many major projects e.g. HiPerNav, (EU prosjekt), NorMit, MetAction and BigMed

Collaborations

In all the projects, the group has a large international network of collaborators e.g.

  • Nasjonalt kompetansetjeneste for ultralyd og bildeveiledet behandling, Trondheim
  • Tumorbiologi, Radiumhospitalet, OUSPubGene, Oslo
  • A strong cooperation between the different research groups in The Intervention Centre:
  • Prof Robert Troisi, Dept. of General and Hepato-Biliary Surgery and Liver Transplantation Service,
  • Ghent University Hospital Medical School, Belgium.
  • Ass. Prof Mohammad Abu Hilal, Faculty of Medicine, Southampton University, Research and development lead for Surgery, Southampton University Hospital –Great Britain
  • Prof Luca Aldrighetti Chief of Liver Unit, Department of Surgery, Scientific Institute SanRaffaele, University Vita-Salute San Raffaele, Milan, Italy.
  • Prof Alessandro Ferrero, Direttore f.f. S.C. Chirurgia Generaleed OncologicaOspedale Mauriziano, Torino, Italy.

PhD students:

  • Tom Nordby
  • Kim Ånonsen
  • Gudrun Maria Waaler
  • Mushegh Sahakyan
  • Åsmund Avdem Fretland
  • Jens Marius Næssgaard
  • Rafael Palomar
  • Andrea Teatini
  • Egidijus Pelanis
  • Davit Aghayan
  • Hilde Kjernlie Andersen
  • Martin Johansson
  • Vanja Cengija
  • Sven Petter Haugvik
  • Leonid Barkhatov
  • Ulrik Carling
  • Vegar Dagenborg
  • Milan Spasojevic

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Radiology Research

MR guided High Intensity Focused Ultrasound treatment

Group Leader: Per Kristian Hol, Professor, MD, PhD

Group Members:

  • Bjørn Edwin, Professor MD PhD, The Intervention Centre (researcher)
  • Eric Dorenberg, MD PhD, Dept of Radiology, OUS Rikshospitalet (researcher)
  • Tryggve Storås, PhD, The Intervention Centre (researcher)
  • Grethe Løvland (technician)
  • Jorunn Fraser-Green (technician)
  • Kenneth O Pedersen (technician)
  • Ulrik Carling, MD (PhD candidate)
  • Per Istre, MD (researcher)
  • Silje Velle Dypbukt, MD (researcher)

Associated group members:

  • Viktor Berge, MD PhD, and Eduard Baco, MD, Dept of Urology, OUS Aker (researcher)
  • Kirsten Hald, MD, PhD, Dept of Gynecology, OUS Ullevål (researcher)
  • Ellen Viktil, MD, Dept of Radiology, OUS Ullevål (researcher)
  • Johann Baptist Dormagen, MD, PhD, Dept of Radiology OUS Ullevål (researcher)

Background

High Intensity Focused Ultrasound (HIFU)-therapy is completely non-invasive as the ultrasound energy is delivered outside the body, but focused in defined areas in an organ. MR provides three-dimensional treatment planning and real-time temperature feedback. Integrating HIFU in MR-scanners melds the technology for visualization and treatment, optimize the procedure and increase the therapeutic potential of HIFU treatment. The 3 T MR at the Intervention Centre has integrated HIFU equipment as part of a research agreement with Philips Medical Systems. Focus has been on both basic and clinical research projects.

Ongoing Projects:

  • MR guided HIFU in the treatment of uterine fibroids
  • Basic research on MR guided HIFU of liver
  • Basic research on MR guided HIFU of prostate
  • Collaborations:
  • Philips Healthcare, Nederland: Dr Thomas Andrea
  • Profound Medical, Canada

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Anesthesiology Research

Clinical and experimental cardiovascular monitoring

Group Leader: Per Steinar Halvorsen

Research group members

Senior researchers

  • Jan Fredrik Bugge, Dep. of Anesthesia and Critical Care Medicine
  • Andreas Espinoza, Dep. of Anesthesia and Critical Care Medicine.
  • Helge Skulstad, Dep. of Cardiology.

Associated group members

  • Professor Erik Fosse, The Intervention Centre.
  • Professor Thor Edvardsen, Department of Cardiology.
  • Professor Arnt Fiane, Department of Cardiothoracic Surgery.
  • Ass. professor Ole Jacob Elle, The Intervention Centre.
  • Professor Svend Aakhus, Department of Cardiology.
  • Lars Aaberge, Department of Cardiology.
  • Jan Otto Beitnes, Department of Cardiology.
  • Espen Remme, Department of Cardiology/The Intervention Centre.

PhD-candidates

  • Viesturs Kerans, MD, The Intervention Centre. viesturs.kerans@medisin.uio.no. HYPOTHERMIA
  • Jo Eidet, MD, Dep. of Anesthesia and Critical Care Medicine.  jeidet@ous-hf.no TAVI
  • Harald Bergan, MD, Dep. of Anesth. and Critical Care Medicine. haaber@ous-hf.no. ECMO
  • Ole-Johannes Grymyr, MD, The Intervention Centre. olegry@ous-hf.no. SENSORS
  • Stefan Hyler, MD, The Intervention Centre and Sørlandet sykehus, st.hyler@bluewin.ch SENSOR
  • Itai Schalit, MD, The Intervention Centre. itasch@ous-hf.no. LVAD/SENSORS
  • Kristin Wisløff-Aase, MD, Dep.of Anesthesia and Critical Care Medicine. HYPOTHERMIA
  • Siv Hestenes, MD, The Intervention Centre/Sykehuset Akser og Bærum.smereteh@online.no. SEPSIS
  • Hilde Karlsen, MD, Dep.of Anesthesia and Critical Care Medicine. hikarl@ous-hf.no. ECMO
  • Marte Sævik, MD, The Intervention Centre/Dep. Of Cardiology, masa2@ous-hf.no. TAVI
  • Pengfei Lu, MScThe Intervention Centre, pengfei.lu2016@gmail.com. PACEMAKER/CRT
  • Mohammad Albatat, MSc, The Intervention Centre, malbatat.90@gmail.com. PACEMAKER/CRT

Background

A trend in cardiovascular therapies involves development of minimal invasive surgical techniques for valve repair and treatment of severe heart failure by biventricular pacing. Even though a method can be classified as minimal invasive, the procedural risks still may be high, as demonstrated by treatment of severe aortic stenosis by catheter technique (TAVI) instead of open chest surgery. Another trend in severe heart failure treatment is implantation of mechanical pumps, as either bridge to transplantation or as destination therapy as an alternative to heart transplantation. In contrast to the other therapies, implantation of a mechanical pump is a highly invasive procedure and justifies more invasive monitoring of the patient. In both cases, assessment of cardiovascular status is equally important, but requires different approaches which need to be adapted to the risks and invasiveness of the procedures. New methods for cardiovascular monitoring in the operative setting may also be used to guide and optimize treatment in hemodynamically compromised patients in the intensive care unit, such as in patients with septic or cardiogenic shock, and patients treated with therapeutic hypothermia after cardiac arrest.

Main aims

  • Develop and test new technologies in cardiovascular monitoring
  • Cardiovascular response to new cardiovascular therapies
  • Myocardial function in therapeutic hypothermia and severe sepsis

This includes evaluating hemodynamic responses of 1) new cardiovascular image guided procedures, 2) ECMO strategies, 3) treatment for end stage heart failure with ventricular assist devices (VAD). Technologies under investigation for cardiac function monitoring include implantable 3D accelerometers, gyro, magnetometer, miniaturized ultrasound sensors, biosensors and radar. The sensors are tested in both clinical and experimental models in cooperation with other research groups at The Intervention Centre, departments at OUS and external institutions.

Ongoing research projects

  • TAVI: is myocardial reserve related to long term outcome?
  • Accelerometer for detection of thromboembolic events in LVAD
  • Accelerometer/gyro/magnetometer for monitoring changes in right and left ventricular load and detection of graded myocardial ischemia.
  • Can betablockers improve survival and cardiovascular function after cardiac arrest: an experimental ECMO study
  • Left and right ventricular dysfunction in severe sepsis; the effect of pulmonary hypertension and interventricular septal shift
  • Myocardial effects of therapeutic hypothermia in cardiac surgery
  • Effects of epinephrine and betablockers on systolic and diastolic left ventricular function during therapeutic hypothermia
  • Multifunctional pacemaker systems for cardiac resynchronization therapy (CRT)

Collaborations

  • OSCAR research network at Oslo University Hospital: Professor K. Sunde
  • Complement Research Group at Oslo University Hospital: Professor Tom Eirik Mollnes
  • Biosensor Research Group at Oslo University Hospital: Professor T. I. Tønnessen
  • WiBEC EU-project at The Intervention Centre: Professor Ilangko Balasingham,
  • University College of Southeast Norway: Professor Kristin Imenes

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Medical Cybernetics and Image Processing Research

Group Leader: Professor Ole Jakob Elle, PhD

Group Members

  • Rafael Palomar, PhD-fellow/Software developer/Computer Graphics/Navigation
  • Rahul Kumar, Postdoc, Liver Image segmentation/Navigation
  • Espen Remme, Senior Researcher in 30% (shared IVS/Kirurgisk forskning), Heart Physiology
  • Magnus Krogh, PhD fellow, Cardiac sensor and signal processing
  • Robin Bugge, Image processing in 20%, MSc., 3D-print/Heart segmentation
  • Pravda Jit Ray, PhD-fellow, HiPerNav
  • Andrea Teatini, PhD-fellow, HiPerNav
  • Egidijus Pelanis, PhD-fellow, HiPerNav
  • Kim Mathiassen, PhD-fellow (also at ROBIN-group at IFI/UIO), US-robot
  • Justinas Miseikis, PhD-fellow (also at ROBIN-group at IFI/UIO), Collision avoidance
  • Congcong, PhD-fellow (also at NTNU-Gjøvik), Denoising of lap. stereo video/3D surface extraction

Research aims

Most minimally invasive procedures restrict the access and direct vision to the regions which require surgery. Such procedures require intra-operative image modalities such as x-ray, ultrasound or endoscopic images to be able to monitor the procedure in real-time.  In many cases this information is not sufficient to perform the procedure accurately and safely. Merging information acquired pre-operatively, mainly from for instance MRI, CT or PET, with intra-operative data can increase the basis for decisions and thereby improve the safety and accuracy of the procedure. The Medical Robotics, visualization and navigation group develops cutting edge technological solutions which support minimally invasive procedures. In particular, the group is focused on developing real-time image-segmentation and - registration methods. Visualization and navigation is required to present the medical images to the surgeon intra-operatively. 3D video will be more and more cross-linked with medical image information and move toward robotics and automation of surgical procedures. The research group is doing research in all these fields of technology facilitating minimally invasive surgery.

Ongoing Projects

Ongoing NFR:

  • NorMIT, National Research Infrastructur for Minimally Invasive Treatment
  • Ongoing Helse Sør-Øst:
  • Hepa-Navi, Liver Navigation platform (Postdoc)
  • Fast vessel segmentation algorithm (Innovation)
  • Service at OUS – 3D printing of organ models (Innovation)
  • Modulbasert Operasjonslys for Hybride Operasjonsstuer (Innovation)
  • Måling av hjertefunksjon ved hjelp av en ny miniatyrisert bevegelsessensor (Innovation)
  • Mimiq: Tilpasningsdyktig LED sporing for navigasjon og medisinsk robotikk (Innovation)
  • HoloViz and HoloNav: 3D Mixed reality Visualization of medical images in planning and treatment (Innovation)

Other ongoing projects:

  • Semi-autonomous ultrasound robot for nedle insertion
  • EU-project funded:
  • As participant of the Marie Curie ITN-project: PIC (Personalized Cardiology)
  • As coordinator of the Marie Curie ITN-project: HiPerNav (High Performance soft-tissue Navigation), start date 01.11.2016

Collaborations

  • University of Bern (ARTOrg)
  • Technical University of Delft (TUDelft)
  • University Paris13
  • University of Cordoba
  • Cascination AG
  • Inselspital, University of Bern
  • INRIA
  • SIEMENS
  • University of California, San Diego (UCSD)
  • University of Dundee
  • University of St. Andrews
  • Norwegian University of Science and Technology
  • University of Homburg, SAAR
  • MR Comp GmbH
  • GE Medical Systems
  • Katholieke Universiteit Leuven, Leuven, Belgium
  • Zürcher Hochschule für Angewandte
  • Wissenschaften, Winterthur, Switzerland
  • Imperial College London, London, United Kingdom
  • Institute of Biomechanics, Center of Biomedical Engineering, Graz, Austria
  • Endosense SA, Geneva, Switzerland
  • Scuola Superiore Sant’Anna, Pisa, Italy
  • University of Verona
  • Tallin University
  • San Raffaele Hospital
  • Yeditepe University
  • ETH Zurich
  • King’s College London
  • University of Oxford
  • GE Vingmed
  • Sintef Medical Technology
  • Sheffield Hallam University
  • Universidad de Zaragoza
  • Universidad politecnica de Madrid

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Information and Communication Technology Research

Wireless Biomedical Sensor Network Research Group

Group Leader:  Professor Ilangko Balasingham

Signal Processing Group, Dept. of Electronic Systems, NTNU

Group members

Sr. Researchers

  • Jacob Bergsland, MD, PhD
  • Ali Khaleghi, PhD

Postdoctoral Fellows

  • Ali Chelli, PhD
  • Younghak Shin, PhD
  • Nabiul Islam, PhD

PhD Students:

  • Øyvind Janbu
  • Pritam Bose
  • Mladen Veletic
  • Pengfei Lu
  • Hamed Fouladi
  • Hemin Qadir
  • Mohammad Albatat
  • Salman Mahmood
  • Deepak Palaksha
  • Muhammad Faheem Awan

Background

The research group performs fundamental research and development in information and communication technologies, specifically in wireless sensors and systems for applications in diagnosis, minimal invasive therapy, and ambient point of care monitoring. One of the technological focused areas is on ultra-low power and reliable wireless implant sensor networks, where the research is on novel transceiver design, low power data compression, and data processing algorithms for event and anomaly detection, data fusion, etc. Special interest topics are in implantable/ingestible sensors like cardiac pressure sensors, capsule endoscopes, bio-nano scale communications, and nanomachine-to-cell interfaces for stimulation for applications in cardiac, gastrointestinal, and neurodegenerative diseases.  Moreover, the group also performs research in patient record and data mining, signal and image processing, and developing novel sensing and imaging systems using electromagnetic waves.

International collaboration

  • Prof. Jianqing Wang, Nagoya Institute of Technology, Japan
  • Prof. Narcis Cardona, Universitat Politècnica de València, Spain
  • Prof. Ram Narayanan, Penn State University, USA
  • Prof. Wout Joseph, Ghent University, Belgium
  • Prof. Dirk Pletemeier, Technical University of Dresden, Germany
  • Prof. Ian F. Akyildiz, Georgia Institute of Technology, USA
  • Prof. Christopher Contag, Michigan State University/Stanford University, USA

Selected Externally Funded Research Projects

  1. Project Manager/PI of Wireless In-body Sensor and Actuator Networks (WINNOW). (Funded by the Research Council of Norway, IKTPLUSS, 01.04.2017-30.04.2022, Award NOK 16 million)
  2. Coordinator/PI of Wireless In-Body Environment (WiBEC),  (Funded by the European Commission, H2020- MARIE Skodowska-CURIE ACTIONS  (MSCA-ITN-2015), 01.01.2016-31.12.2019, budget €3.957 million)
  3. PI/Work Package Leader of Holistic Monitoring of Indoor Environment (HOME), (Funded by the Research  Council of Norway, Idea Lab program, 01.06.2014 - 31.12.2017, Award NOK 10 million)
  4. Project Manager/Principle Investigator of Medical Sensing, Localization, and Communications Using Ultra Wideband Technology (MELODY II), (Funded by the Research Council of Norway, VERDIKT program, 01.01.2013 - 31.12.2017, Award NOK 14.7 million)

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Method Development and Industry Collaboration Research

Clinical Testing Work Group

Group Leader: Karl Øyri, PhD

In 2017 36 new project inquiries from companies were made to the TestBed. Seven were terminated 14 projects are currently in the planning phase, 2 are ongoing, and 13 projects were completed in 2017. The complex projects involving early phase technologies often have long planning phases due to protocol development and adjustments, regulatory requirements and resource mapping at the hospital.

Inven2, the technology transfer office (TTO) at Oslo University Hospital handles legal contracts and economy for the industry-sponsored projects in the testbed. We continue the close collaboration with Norway Healthech. SMI is present at Aleap in Forskningsparken on a weekly basis to meet with companies and Norway Healthtech.

The quality coordinator in SMI is continuously involved in refinement of the quality systems at The Intervention Centre. A God Clinical Practice (GCP) framework has been implemented in the Quality System, and can be used if companies are in need of GCP compliant services.

Ongoing Projects:

The Nordic Network of Testbeds Project funded by Nordic Innovation was finalized in 2017. With continued funding from Nordic Innovation the project ended with the establishment of Nordic Proof where all project partners are collaborating in a consortium of testbeds.  Nordic Proof provides professional services for testing of new and innovative healthcare products in the Nordic region. With a “one point of contact” for all the test beds, Nordic proof aim to match (supply? provide?) the companies with a variety of test facilities to meet industry needs.

Collaborations

  • Inven2 TTO
  • Innovasjonsavdelingen, Oslo University Hospital,
  • Norway Healthech
  • Sunnaas Sykehus
  • Nordic Medtest, Karlstad, Sweden
  • SLL Innovation, Stockholm Läns Landsting, Stockholm, Sweden
  • Innovationsplatsen , Karolinska University Hospital, Stockholm, Sweden
  • HUS, Hospital District of Helsinki and Uusimaa, Helsinki, Finland
  • Region H, Capital Region of Denmark, Copenhagen, Denmark

Development of organizational performance and innovative logistics

Group Leader: Karl Arne Johannessen

New ambitions: SMI has an ambition to expand its competence and capabilities to a new dimension; how may our experience and competence related to technological innovations be extended to the organizational perspective?

Whereas new solutions from technology research are accelerating, the impact of their implementation will not be achieved at full potential if the involved organizational solutions are unchanged. Despite implementation of numerous new technological solutions in a large span of clinical activities, many services remain organized and operate with a traditional approach that may delay and even obstruct improvements in resource utilization and quality. We have the ambition to identify basic cultural and organizational characteristics that may trigger innovative transformation of clinical services in concordance with technological innovations in a two-fold perspective:

  • How may we improve logistics in services which implement new technological solutions?
  • How may we extend such experience and logic to clinical services that are not directly involved in the technological development, but where services may replicate and benefit from experiences from more technology based services?

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The BigMed Project

Group Leader: Thomas Smedsrud

The BigMed project is an ICT Lighthouse project funded by The Research Council of Norway to promote development and technology and services with advanced computer science. The project is managed and owned by the Intervention Centre at Oslo University Hospital, and includes a broad consortium of partners from several other departments in the hospital, three faculties at the University of Oslo, industry organisations and four patient associations. The project aims to lay a foundation for implementing precision medicine and big data analytics in healthcare, and will do so through testing and developing of ICT solutions to support the implementation of precision medicine in three clinical areas: rare diseases, sudden cardiac death and metastatic colorectal cancer. When developing solutions, the cross-competence teams in BigMed will discuss barriers and identify actions to overcome them. The barriers for implementation of precision medicine include legal, ethical and social aspects that must be discussed and addressed.

Website: www.bigmed.no

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Clinical Test Facility

OUS Test Facility Clinical Test Facility at The Intervention Centre. The Test Facility is a professional gateway for companies with new high tech equipment in need for early phase clinical trials.

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Nordic Proof

Nordic Proof

The Intervention Centre is a partner in Nordic Proof

Norway Health Tech

NHT

The Intervention Centre and Oslo University Hospital are founding members of Norway Health Tech, and work actively with Norway Health Tech to develop medtech industry in Norway.

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Information in Norwegian

English is the main language in this web portal. Some information is also available in Norwegian Norwegian text

Donations to Medical Research

The Interventional Centre receives donations to medical research. Questions related to donations can be sent to head of department professor Erik Fosse.

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Author: Erik Fosse
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